在脊髓损伤后,骨盆器官的 afferent 和 efferent 输入的生长
Shunyi Zhao1,2, Chuanxi Tang3, Jeremy Weinberger1
1Department of Neurobiology and Anatomy, Marion Murray Spinal Cord Research Center, Drexel University College of Medicine, USA.
Journal of neuropathology and experimental neurology
|December 16, 2023
概括
脊髓损伤 (SCI) 导致骨盆器官的神经发芽. afferent 和 efferent 纤维的这些变化可能是受伤后功能适应的基础.
科学领域:
- 神经科学是一个神经科学.
- 身体生理学 身体生理学
背景情况:
- 神经可塑性是已知的脊髓损伤 (SCI) 的反应.
- 中枢神经系统路径的变化已经得到了充分的证据.
- 在SCI后,外周盆腔内神经的形态变化在很大程度上仍然没有特征.
研究的目的:
- 为了研究SCI后提供骨盆器官的 afferent和efferent神经纤维的形态变化.
- 为了检查脏,结肠和膀在脊髓切割后的内化模式.
主要方法:
- 使用了一种老鼠脊髓切割模型.
- 采用免疫组织化学来可视化氨酸氧酶 (TH) 标记的交感纤维和素基因相关 (CGRP) 免疫反应性感官终端.
- 在骨盆器官中分析了神经纤维形态,受伤后3-4周.
主要成果:
- 在骨和结肠中观察到TH阳性交感和CGRP阳性感觉纤维的生长,表现出无组织的结构.
- 在膀的肌肉层和自身膜中检测到增加的CGRP阳性感觉纤维.
- 在膀中发现的TH阳性交感体纤维显示高,但保持了它们的内化模式.
结论:
- 在SCI之后,盆腔器官中的外接和外接神经纤维广泛发芽.
- 这些广泛的发芽模式代表了脊髓损伤后功能适应或不适应的潜在形态基础.
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