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Updated: Jul 8, 2025

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
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A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis

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在IIa期肺结核试验中使用多维细菌负载建模的多维细菌负载建模来确定暴露-反应关系的权力

Simon E Koele1, Thomas P C Dorlo2, Caryn M Upton3

  • 1Department of Pharmacy, Radboudumc Research Institute for Medical Innovation (RIMI), Radboud University Medical Center, Nijmegen, The Netherlands.

CPT: pharmacometrics & systems pharmacology
|December 16, 2023
PubMed
概括

在结核病 (TB) 临床试验中确定暴露-反应关系至关重要. 时间到阳性 (TTP) 标记器为药理动力学-药理动力学 (PK-PD) 建模提供了比殖民地形成单位 (CFU) 更大的功率,特别是在结合数据或不平衡设计的情况下.

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