牙周炎和癌症风险:机械学证据
Giacomo Baima1, Margherita Minoli2, Dominique S Michaud3
1Department of Surgical Sciences, C.I.R. Dental School, University of Turin, Turin, Italy.
Periodontology 2000
|December 16, 2023
概括
牙周炎是一种口腔感染,与癌症风险增加有关,包括头癌,肺癌和消化系统癌症. 口腔细菌和牙周炎的炎症可能导致癌症的发展和进展.
科学领域:
- 口腔微生物学 口腔微生物学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 牙周炎始终与更高的头癌风险有关.
- 新出现的证据表明牙周炎与远程癌症 (如肺,乳腺,前列腺和消化道恶性瘤) 之间存在联系.
研究的目的:
- 批判性地分析连接牙周炎和口腔细菌与癌症发病和进展的相互作用途径和致病机制.
- 探索口腔病原生物和相关炎症如何促进各种身体部位的瘤发生.
主要方法:
- 审查流行病学报告和机制学研究.
- 分析路径包括局部失调,慢性炎症,免疫逃避,遗传损伤,全身炎症和细菌转移.
- 调查特定的口腔病原生物,如 Porphyromonas gingivalis 和 Fusobacterium nucleatum. 这样的人.
主要成果:
- 牙周炎促进局部和全身炎症,免疫逃避和直接的遗传损伤,促进癌症的发展.
- 口腔细菌及其毒性因子可以转移到遥远的部位,影响与瘤相关的微生物组和癌症特征.
- 特定的口腔病原生物通过调节免疫系统和促进瘤基因表达,与胃肠道癌症有关.
结论:
- 牙周炎通过多种相互关联的机制在癌症发病和进展中发挥着潜在的作用.
- 需要进一步的研究才能充分阐明牙周炎,口腔微生物组和癌症之间的复杂关系.
- 考虑共同的风险因素和并发症对于理解这种关联至关重要.
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