核心-外围结构中的异常功能连接基于ADHD中的WSBM
Dandan Li1, Dianni Hou1, Yating Zhang1
1Taiyuan University of Technology, Shanxi, China.
Journal of attention disorders
|December 16, 2023
概括
注意缺陷多动性障碍 (ADHD) 显示了大脑网络社区结构的改变. 这项研究揭示了ADHD中核心-外周结构异常,提供了超越模块化分析的新见解.
科学领域:
- 神经科学是一个神经科学.
- 大脑网络分析 脑网络分析
- 计算精神病学是一种计算精神病学.
背景情况:
- 之前在注意力缺陷多动症 (ADHD) 中的大脑网络研究主要集中在模块化社区结构上.
- 在ADHD中,功能连接 (FC) 的核心-外围组织仍然未被探索,可能会限制对网络变化的全面理解.
研究的目的:
- 研究ADHD患者大脑功能连接的核心-外围社区结构.
- 评估连接强度 (CS) 的变化,并应用中断指数 (DI) 来描述这些核心-外围变化.
主要方法:
- 利用加权随机区块模型将功能连接分成10个不同的社区.
- 使用核心得分指标定义了核心-外围结构.
- 评估CS和DI的变化,以量化核心-外围组织的变化.
主要成果:
- 视觉网络的核心社区表现出降低的CS和积极的DI,表明中断.
- 视觉网络的边缘社区显示了增强的CS.
- 在核心感觉运动/视觉网络与注意网络外围之间的相互作用中观察到增加的CS和负的DI.
结论:
- 核心-外围社区结构中的异常代表了理解ADHD中大脑网络组织的新视角.
- 这些发现表明,ADHD涉及到大脑网络层次组织的特定干扰,影响核心和外围社区的相互作用.
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