肺液中的散播性胸腺瘤:一个不寻常的病例
1Pathology Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Diagnostic cytopathology
|December 16, 2023
概括
这项研究报告了一种罕见的胸腺瘤病例,该病例是在膜液细胞学中发现的. 这些发现突出了诊断的挑战,特别是当上皮成分缺失时,模仿反应性淋巴细胞输液.
科学领域:
- 病理学 病理学 病理学
- 细胞病理学 细胞病理学
- 在瘤学瘤学.
背景情况:
- 胸膜上皮瘤 (TETs) 有明显的细针吸收细胞学特征.
- 在流体细胞学中对胸腺瘤的细胞学诊断没有得到充分的记录.
- 胸膜溢出可能是胸腺瘤转移的次要原因.
研究的目的:
- 描述胸腺瘤在多液中的细胞学特征.
- 报告肺液中缺少上皮组成部分的胸腺瘤病例.
- 讨论诊断挑战和免疫组织化学发现.
主要方法:
- 流的细针吸入细胞学.
- 细胞学涂抹评估.
- 针对T细胞标记物 (CD3,CD1a,TdT) 的免疫组织化学 (IHC) 染色.
主要成果:
- 胸腔液细胞学揭示了大量的小淋巴细胞和间皮细胞,没有上皮组成部分.
- IHC证实了淋巴细胞是未成熟的T细胞,其起源于胸腺 (CD3+,CD1a+,TdT+).
- 尽管没有上皮细胞,但诊断出怀疑复发/转移性胸腺瘤的诊断.
结论:
- 胸腺瘤可以在多液细胞学中识别,即使没有上皮组成部分.
- 未成熟的T细胞标记物对于在输液细胞学中诊断胸腺瘤至关重要.
- 这种表现是区分与反应性淋巴细胞输液的潜在陷.
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