相关实验视频

Updated: Jul 8, 2025

A Protocol for Detecting and Scavenging Gas-phase Free Radicals in Mainstream Cigarette Smoke

A Protocol for Detecting and Scavenging Gas-phase Free Radicals in Mainstream Cigarette Smoke

Published on: January 2, 2012

理论和实验洞察力对鲁比亚丁的激进清理活动的理论和实验洞察力

Le Trung Hieu¹, Nguyen Thi Hoa², Adam Mechler³

¹University of Sciences, Hue University, Thua Thien Hue 530000, Vietnam.

The journal of physical chemistry. B

|December 16, 2023

概括

鲁比亚丁 (RBD) 是一种天然化合物,作为一种选择性的激素清除剂. DFT计算显示其对抗各种激素的中度抗氧化活性,特别是在极地环境中.

科学领域:

* 计算化学计算机化学
* 植物化学植物化学
* 抗氧化剂研究

背景情况:

* 鲁比亚丁 (RBD) 是一种来自Rubia cordifolia*的 antraquinone衍生物.
* RBD 具有抗癌,神经保护,抗炎和抗糖尿病的特性.
* 它的抗氧化活性需要全面研究.

研究的目的:

* 评估RBD激素清理活动的机制和动力学.
* 评估RBD在不同溶剂中对HO•和HOO•激素的有效性.
* 为了确定RBD的整体抗氧化能力.

主要方法:

*使用密度函数理论 (DFT) 的计算.
* 分析激素清除机制和动力学.
* 跨脂质和极性溶剂环境的研究.

主要成果:

* RBD在脂质 (2.95 × 108 M−1s−1) 和极性 (1.82 × 1010 M−1s−1) 介质中表现出适度的HO•激素清理.
* 在水溶液中显著的超氧化离子基清除 (k = 4.93 × 108 M-1s-1).
*在DPPH/ABTS•+测定中观察到中度活性,对其他基因 (CCl3O•,CCl3OO•,NO2,SO4•−,N3•) 进行了多样化的清理.

结论:

* RBD是一种选择性的激素清除剂,在极地介质中具有显著的活性.
*计算方法提供了对RBD抗氧化机制的见解.
* 进一步的研究可以根据其抗氧化剂配置来探索RBD的治疗潜力.

更多相关视频

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development

Published on: April 15, 2013

Exploring the Radical Nature of a Carbon Surface by Electron Paramagnetic Resonance and a Calibrated Gas Flow

Exploring the Radical Nature of a Carbon Surface by Electron Paramagnetic Resonance and a Calibrated Gas Flow

Published on: April 24, 2014

相关概念视频

Radical Reactivity: Overview

Radical Reactivity: Overview

Radicals, the highly reactive species, gain stability by undergoing three different reactions. The first reaction involves a radical-radical coupling, in which a radical combines with another radical, forming a spin‐paired molecule. The second reaction is between a radical and a spin‐paired molecule, generating a new radical and a new spin‐paired molecule. The third reaction is radical decomposition in a unimolecular reaction, forming a new radical and a spin‐paired...

Radical Reactivity: Steric Effects

Radical Reactivity: Steric Effects

The presence of electron-donating, electron-withdrawing, or conjugating groups adjacent to a radical center, imparts electronic stabilization to the radicals. Examples of such electronically-stabilized radicals are triphenylmethyl, tetramethylpiperidine‐N‐oxide, and 2,2‐diphenyl‐1‐picrylhydrazyl. These radicals are remarkably stable and are known as persistent radicals. Some of the persistent radicals can even be isolated and purified.
Along with electronic...

Radical Reactivity: Nucleophilic Radicals

Radical Reactivity: Nucleophilic Radicals

Radicals adjacent to electron-donating groups are called nucleophilic radicals. These radicals readily react with electrophilic alkenes. The SOMO–LUMO interactions are the driving force for the reaction, where the high-energy SOMO of the electron-rich, nucleophilic radicals interacts with the low-energy LUMO of the electron-deficient, electrophilic alkenes. Such SOMO–LUMO interactions are the basis of reactive radical traps, affecting the selectivity in radical reactions. For...

Radical Autoxidation

Radical Autoxidation

The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...

Radical Reactivity: Concentration Effects

Radical Reactivity: Concentration Effects

In a radical reaction, the concentration of starting materials governs the selectivity of a radical. For example, the reaction between an alkyl halide and an alkene, in the presence of tin hydride and AIBN, begins with the generation of a tin radical. The generated radical then abstracts halogen from the alkyl halide, producing an alkyl radical. This alkyl radical can either react with tin hydride, yielding an alkane, or add to an alkene, generating a nitrile-stabilized radical, eventually...

Radical Formation: Addition

Radical Formation: Addition

Radicals can be formed by adding a radical to a spin-paired molecule. This is typically observed with unsaturated species, where the addition of a radical across the π bond leads to the production of a new radical by dissolving the π bond. For example, the addition of a Br radical to an alkene yields a carbon-centered radical.
Similar to charge conservation in chemical reactions, spin conservation is implicit for radical reactions. Accordingly, the product formed must possess an...