Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Detergent Purification of Membrane Proteins01:18

Detergent Purification of Membrane Proteins

5.2K
Detergents are used to purify the integral proteins of the membrane. The hydrophobic portion of the detergent can replace membrane phospholipids while solubilizing the membrane proteins. When detergent monomers reach a specific concentration in a solution called critical micelle concentration (CMC), they form micelles. Above CMC, the concentration of the detergent monomers remains in equilibrium with the micelle. The number of detergent monomers present in the CMC varies for each detergent, and...
5.2K
Comparing Intermolecular Forces: Melting Point, Boiling Point, and Miscibility02:34

Comparing Intermolecular Forces: Melting Point, Boiling Point, and Miscibility

44.4K
Intermolecular forces are attractive forces that exist between molecules. They dictate several bulk properties, such as melting points, boiling points, and solubilities (miscibilities) of substances. Molar mass, molecular shape, and polarity affect the strength of different intermolecular forces, which influence the magnitude of physical properties across a family of molecules.
Temporary attractive forces like dispersion are present in all molecules, whether they are polar or nonpolar. They...
44.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Lipid packing contributes to the confinement of caveolae to the plasma membrane.

eLife·2026
Same author

Double emulsions enable in situ generation of permeation enhancers for oral delivery of macromolecules.

Journal of colloid and interface science·2026
Same author

Exhaled particle size and phospholipid composition of the respiratory tract lining fluid following moderate-intensity exercise in sub-zero conditions.

Journal of breath research·2026
Same author

Identification of drug repurposing candidates for the treatment of polycystic kidney disease.

British journal of pharmacology·2026
Same author

Tailored pediatric clonazepam tablets produced by 3D printing: Meeting quality standards and improving permeation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Aggregation behavior of sodium caprate under different pH, concentration, and intestinal fluid conditions: a coarse-grained molecular dynamics study comparing Martini 2 and Martini 3.

Physical chemistry chemical physics : PCCP·2026

相关实验视频

Updated: Jul 8, 2025

Contrast-Matching Detergent in Small-Angle Neutron Scattering Experiments for Membrane Protein Structural Analysis and Ab Initio Modeling
10:27

Contrast-Matching Detergent in Small-Angle Neutron Scattering Experiments for Membrane Protein Structural Analysis and Ab Initio Modeling

Published on: October 21, 2018

12.4K

分子动力学研究微粒-小分子相互作用:为广泛的比较制定战略.

Aleksei Kabedev1, Christel A S Bergström1,2, Per Larsson3,4

  • 1Department of Pharmacy, Uppsala University, Uppsala, Sweden.

Journal of computer-aided molecular design
|December 16, 2023
PubMed
概括

优化分子动力学 (MD) 模拟可以改善肠道小粒体中药物溶解的预测. 这项研究平衡了准确性和计算成本,以改善药物输送和生物可用性研究.

关键词:
进行广泛的查.肠道液体 肠道液体分子动力学模拟的模拟.溶解化 溶解化雨抽样是统一的抽样方式.

更多相关视频

Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
08:01

Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis

Published on: November 17, 2017

7.4K
Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

2.3K

相关实验视频

Last Updated: Jul 8, 2025

Contrast-Matching Detergent in Small-Angle Neutron Scattering Experiments for Membrane Protein Structural Analysis and Ab Initio Modeling
10:27

Contrast-Matching Detergent in Small-Angle Neutron Scattering Experiments for Membrane Protein Structural Analysis and Ab Initio Modeling

Published on: October 21, 2018

12.4K
Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
08:01

Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis

Published on: November 17, 2017

7.4K
Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

2.3K

科学领域:

  • 计算化学是一种计算化学.
  • 生物物理化学 生物物理化学
  • 药物输送科学 药物输送科学

背景情况:

  • 准确预测药物溶解在肠液中的情况对于开发有效的药物输送系统和提高生物可用性至关重要.
  • 对于广泛的研究,现有的计算方法在平衡精度与计算成本方面面临着挑战.

研究的目的:

  • 确定一个最佳的分子动力学 (MD) 协议,用于评估小分子与肠道小粒的相互作用.
  • 为了比较不同的模拟设置,以预测溶解能力的效率和准确性.

主要方法:

  • 用分子动力学 (MD) 模拟来生成药物和表面活性剂分子的自由能量概况.
  • 模拟策略的比较包括自由组装与预先组织的米塞尔,完整的配置文件与点智能的计算,以及全原子 (AA) 与粗粒度 (CG) 模型.
  • 采用了总体抽样 (美国) 和分点自由能源 (FE) 计算.

主要成果:

  • 结合不同的模拟技术为优化性能和精度提供了有利的方法.
  • 该研究确定了特定的MD协议,适用于评估肠道合物中的药物溶解度.
  • 对比了AA和CG雨采样 (US) 模拟和分点自由能量 (FE) 计算的效率.

结论:

  • 一个优化的MD协议可以有效地预测肠液中和囊泡的溶解能力.
  • 这种方法有助于开发新的药物递送技术,并改善生物可用性预测.
  • 这些发现为计算分析活性药物成分在肠道环境中的溶解提供了一个框架.