心血管并发症及其预后价值在小细胞肺癌患者的化学放射治疗
Hanyang Liang1, Tianjie Wang1, Dong Liu1
1State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167 North Lishi Road, Xicheng District, Beijing, 100037, China.
心血管疾病 (CVD) 对小细胞肺癌 (SCLC) 患者的生存率有显著影响. 管理这些并发症对于改善SCLC的长期结果至关重要.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 小细胞肺癌 (SCLC) 是高度恶性,倾向于转移.
- 由SCLC引起的心脏入侵带来了系统性栓塞和阻塞等风险.
- 心血管并发症 (CVD) 是一个越来越严重的问题,影响了SCLC患者的生存和治疗.
研究的目的:
- 调查SCLC患者心血管疾病 (CVD) 的患病率.
- 评估心血管疾病对SCLC患者存活率的影响.
- 确定与SCLC患有心血管疾病的患者死亡率相关的风险因素.
主要方法:
- 在2011年至2018年期间,招募了772名SCLC患者的队列.
- 用单变量和多变量考克斯比例危险模型来分析死亡风险因素.
- 计算了危险比率 (HR) 和95%信心区间 (95%CI).
主要成果:
- 在SCLC患者中,心血管疾病在34.6%的患者中存在.
- 患有心血管疾病的患者的中位生存时间明显缩短 (9.0个月与15.0个月).
- 周心输出和心力衰竭是死亡的独立风险因素;VTE与预后较差有关.
结论:
- 心血管并发症显著影响SCLC患者的存活率.
- 对心血管疾病的有效管理对于改善SCLC患者的长期预后至关重要.
- 对SCLC患有心血管疾病的患者综合护理模式的进一步研究是有必要的.
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