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Updated: Jul 8, 2025

Generation of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells
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使用CRISPR-Cas9生成人性化HCC小鼠模型和癌症驱动突变的协议

Yicheng Zhu1, Stanley M Tahara1, Hidekazu Tsukamoto2

  • 1Departments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, Los Angeles, CA, USA.

STAR protocols
|December 16, 2023
PubMed
概括

我们开发了一个人性化的小鼠模型,用于与代谢性肝病 (MLD) 相关的肝细胞癌 (HCC). 这种模型可以研究基因与环境相互作用,从而推动MLD-HCC.中瘤的发展.

关键词:
癌症 癌症 癌症 癌症干细胞是干细胞.

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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