甲状腺激素敏感性受损增加了冠状动脉血管扫描的患者心血管事件的风险
Zhizhen Qin1, Dilidaer Muhanhali1, Yan Ling1
1Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
The Journal of clinical endocrinology and metabolism
|December 16, 2023
概括
甲状腺激素敏感性受损会增加心血管疾病的风险. 这项研究发现,与甲状腺激素敏感性降低相关的重大不良心血管事件 (MACE) 和心血管死亡风险更高.
科学领域:
- 心血管内分泌学心血管内分泌学
- 甲状腺功能评估评估 甲状腺功能评估
- 临床风险分层化临床风险分层化
背景情况:
- 在甲状腺功能和心血管风险方面存在不一致的发现.
- 甲状腺激素在心血管健康中起着至关重要的作用.
- 评估甲状腺激素敏感性可能会改进风险预测.
研究的目的:
- 研究甲状腺激素敏感性与心血管风险之间的关联.
- 评估主要不良心血管事件 (MACE) 和心血管死亡的风险.
- 专注于接受冠状动脉血管学的人群.
主要方法:
- 对1470名接受冠状动脉动脉扫描的甲状腺功能良好的参与者进行前性队列研究.
- 甲状腺激素耐药性指数 (TT4RI),TSH指数 (TSHI) 和反量基指数 (TFQI) 的计算,以评估甲状腺激素敏感性.
- 用卡普兰-梅尔曲线和多变量考克斯比例危险模型进行分析.
主要成果:
- 高水平的TFQI,TT4RI和TSHI与MACE的风险增加有关.
- 升高的TFQI和TSHI与更高的心血管死亡风险有关.
- 这项研究分析了1089名参与者的平均随访时间为111个月的结果.
结论:
- 甲状腺激素敏感性受损是MACE和心血管死亡的重要危险因素.
- 这一发现对于接受冠状动脉动脉扫描的甲状腺功能良好的患者来说很重要.
- 甲状腺激素敏感性可能成为评估心血管风险的新生物标志物.
相关概念视频
Imaging Studies for Cardiovascular System I:Echocardiography
336
Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
336
Imaging Studies for Cardiovascular System III: X-Ray
188
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
188
Synthesis and Regulation of Thyroid Hormones
4.6K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.6K
Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers
828
β-receptor blockers significantly impact the cardiovascular system by counteracting catecholamine-induced sympathetic responses. These medications decrease heart rate, contractility, and cardiac output, potentially leading to cardiac depression, life-threatening bradycardia, and death. Therapeutically, β-blockers function as mild antihypertensives and are utilized in treating angina pectoris and cardiac arrhythmias. However, nonselective β-blockers inhibit β2-receptors in...
828
Exercise Stress Test
228
Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
228
Antianginal Drugs: Nitrates and β-Blockers
596
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
596


