用于小儿耳痛试验的结果测量:系统性审查
Elliot Heward1, James Dempsey2, John Molloy1
1Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK; Royal Manchester Children's Hospital, Manchester University Hospitals NHS Foundation Trust, UK.
International journal of pediatric otorhinolaryngology
|December 16, 2023
概括
这次审查发现,大多数关于儿科耳部感染的研究中",耳停止"是主要结果. 未来的研究应该将这一措施标准化,以便更好地比较患有耳部泄漏的儿童的治疗方法.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 儿科医学 儿科医学
- 基于证据的医学基于证据的医学.
背景情况:
- 儿科耳鼻 (PO) 涉及中耳感染,耳膜穿孔和儿童耳部泄漏.
- 长时间的PO可能导致听力损失和发育迟缓.
- 目前的管理因证据基础薄弱而变化不定,这突显了对标准化结果报告的需要.
研究的目的:
- 确定用于评估儿科耳鼻的非手术治疗方法的研究中使用的结果指标.
- 评估已识别的结果测量仪器在PO临床试验中的适用性.
主要方法:
- 在PROSPERO注册的系统审查 (CRD42023407976).
- 在EMBASE,MEDLINE和Cochrane数据库中进行了搜索 (1995年1月至2023年5月).
- 包括用于PO儿童的随机对照试验和研究协议,使用Cochrane工具评估偏差风险.
主要成果:
- 从377篇已识别的论文中,包括了6项研究.
- 大多数研究的主要结局是耳停止 (停止的时间和恢复的比例).
- 确定了两个适用的测量工具:耳炎媒体-6问卷和IMTA生产力成本问卷.
结论:
- 为了同质性和比较,建议在未来的研究中将"耳停止的时间"作为主要结果进行标准化.
- 需要进一步的研究来确认这个结果是否对儿童和照顾者最有意义.
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