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在学龄前和学龄儿童患有先天性隔膜的执行功能,适应功能和行为结果的患病率和模式
Enrico Danzer1, Jane E Schreiber1, Casey Hoffman1
1The Richard Wood Jr. Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Early human development
|December 16, 2023
概括
出生腹膜 (CDH) 幸存者表现出适合年龄的适应能力,但与规范相比,执行功能和注意力较低. 在CDH患者中,这些神经行为结果需要进一步关注,以改善长期护理.
科学领域:
- 儿科手术 儿科手术
- 发育儿科 发育儿科
- 神经科学是一个神经科学.
背景情况:
- 遗传腹膜 (CDH) 幸存者的执行功能,适应功能和行为结果都未得到充分研究.
- 早期识别神经发育挑战对于这个人群至关重要.
研究的目的:
- 评估具有CDH的学龄前和早期学龄儿童的执行功能和神经行为功能障碍.
- 将CDH幸存者的结果与标准人口规范进行比较.
主要方法:
- 对100名年龄在3-7岁的CDH幸存者的回顾性队列研究.
- 使用了执行功能的行为评级清单 (BRIEF),自适应行为评估系统 (ABAS-II) 和儿童行为检查清单 (CBCL).
- 将总结分数与规范数据进行比较.
主要成果:
- 学龄前儿童表现出正常的执行功能;学龄儿童的全球执行组合和情绪调节更差.
- CDH幸存者表现出有利的适应性功能.
- 在CDH幸存者中,与正常人相比,注意力问题和注意力缺陷多动性问题明显恶化.
- 疾病严重程度,早产,种族和保险状况与较差的神经行为结果有关.
结论:
- 大多数CDH幸存者表现出适合年龄的执行,适应和行为功能.
- 然而,CDH幸存者作为一个群体,表现出比一般人群更低的执行功能和注意力得分.
- 这些发现强调了在CDH护理中需要有针对性的神经发育支持.
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