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八酸阶段形成水泥作为可注射的骨替代材料:制备和体外结构研究

Öznur Demir¹, Athanasia Pylostomou¹, Dagnija Loca¹

¹Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Pulka St 3, Riga LV-1007, Latvia; Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Riga, Latvia.

Biomaterials advances

|December 16, 2023

概括

可注射酸骨 (CPCs) 显示出对骨再生的前景. 优化液相pH值可以增强水泥的特性,促进骨质细胞的反应,突显了八酸相的重要性.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
整形外科工程整形外科工程

背景情况:

可注射酸骨 (CPC) 是对最小侵入性骨再生有希望的.
阿尔法三酸 (α-TCP) 是CPC的关键成分,在水环境中转化为缺的酸 (CDHAp).
不易降解的水泥,如聚甲基甲酸,缺乏CPC的生物活性.

研究的目的:

使用低温合成的α-TCP.开发一种可注射,自我定位的骨水泥.
为了研究液相pH对基于α-TCP的骨水泥性能的影响.
评估水泥特性对骨质细胞反应的影响.

主要方法:

合成的低温α-TCP粉末作为唯一的粉末前体.
使用不同pH值 (6.0,6.2,7.0,7.4) 的液相制备的骨.
评估了水泥的安置,处理,机械性能,以及体外骨质细胞的附着和增殖.

主要成果:

液相pH值显著影响了α-TCP水泥的设置,处理和机械性能.
确定了八酸 (OCP) 阶段,并与改善的骨质细胞反应呈正相关.
与pH值为7.0和7.4制备的水泥相比,与pH值为6.0和6.2.2制备的水泥表现出优异的骨质细胞附着和增殖.

结论:

液相pH值是调整基于α-TCP的骨水泥特性的一个关键因素.
形成OCP阶段对于提高水泥性能和骨质细胞活性至关重要.
优化的pH条件可以导致改善可注射骨,以增强骨再生.

关键词:

骨再生骨的再生酸是一种酸.酸骨水泥的骨.八酸八酸是一种骨前质细胞的细胞.

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