在加纳中风幸存者中,与升高的脂蛋白a相关的频率和因素
Solomon Gyabaah1, Yaw Adu-Boakye2, Osei Sarfo-Kantanka2
1Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Journal of the neurological sciences
|December 16, 2023
概括
大约30%的加纳中风幸存者患有升高的脂蛋白-a (Lp(a),这是中风风险因素. 这一发现凸显了对这一群体更好的二次预防策略的需求.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 遗传学 遗传学 是一个
背景情况:
- 非洲土著人对高脂蛋白-a (Lp(a) 有遗传倾向,这是已知的缺血性中风风险因素.
- 针对升高的Lp的治疗干预措施 (a) 显示出对治疗动脉样硬化心血管事件的前景.
- 在非洲血统中风幸存者中评估Lp (a) 负担对于优化二次预防和识别治疗差距至关重要.
研究的目的:
- 确定加纳中风幸存者的升高脂蛋白-a (Lp(a)) 的患病率.
- 在这个人群中确定与升高的Lp (a) 相关的因素.
主要方法:
- 在Komfo Anokye教学医院进行了一项前性研究,招募了18岁及以上的缺血性中风幸存者.
- 使用ELISA套件测量血清脂蛋白-a (Lp(a)) 的度.
- 多变量回归分析确定了与Lp (a) 水平超过30 mg/dl的独立相关的因素.
主要成果:
- 在116名中风幸存者中,有35人 (30.2%) 患有升高的Lp (a).
- 与升高的Lp (a) 独立相关的因素包括女性性别 (OR 3.09),糖尿病 (OR 3.52),城市居住 (OR 4.64),和总胆固醇 (OR 1.85).
- 虽然LDL胆固醇降低了,但Lp(a) 水平在12个月内显著增加,从29.38 ± 15.32 mg/dl增加到40.97 ± 29.72 mg/dl (p=0.032).
结论:
- 升高的Lp (a) 影响了大约三分之一的加纳缺血性中风幸存者.
- 相关因素包括女性性别,城市居住,糖尿病和胆固醇升高.
- 这种高患病率表明,在资源有限的环境中,对二次风险降低的治疗需求尚未得到满足.
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