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益生菌治疗作为COVID-19暴露后预防的有效性:双盲,安慰剂控制的随机试验

Paul E Wischmeyer¹, Helen Tang², Yi Ren³

¹Duke University School of Medicine, Department of Anesthesiology, Durham, NC, USA.

Clinical nutrition (Edinburgh, Scotland)

|December 16, 2023

概括

益生菌Lacticaseibacillus rhamnosus GG (LGG) 可以减少COVID-19疾病症状,并在暴露后服用时延迟感染. 这种低成本的干预措施对COVID-19预防策略充满希望.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
传染性疾病传染性疾病

背景情况:

由于COVID-19的流行,疫苗接种之外还需要采取补充的缓解策略.
益生菌显示出降低对呼吸道感染易感性的潜力.
乳酸菌菌 rhamnosus GG (LGG) 作为一种低成本的COVID-19预防方法正在探索中.

研究的目的:

评估益生菌LGG作为COVID-19暴露后预防的疗效.
评估LGG对家庭暴露后症状发展和感染发病率的影响.
调查与LGG补充相关的肠道微生物组变化.

主要方法:

一项随机,双盲,安慰剂对照试验与182名参与者进行了家庭COVID-19暴露后的随机,双盲,安慰剂对照试验.
参与者接受了口服LGG或安慰剂28天.
主要结局:疾病症状的发展;次要:COVID-19诊断和微生物组分析.

主要成果:

治疗LGG显著降低了发展疾病症状的可能性 (26.4%对42.9%,p=0.02).
观察到LGG的COVID-19诊断时间有统计学意义的减少 (日志排名,p=0.049).
总体而言,COVID-19诊断发生率在各组之间没有显著差异 (8.8%与15.4%,p=0.17).

结论:

暴露后补充LGG可能会延长感染时间并减少疾病症状.
益生菌影响了肠道微生物组合.
LGG显示了未来COVID-19预防的潜力,特别是在资源有限的环境中.

关键词:

在 COVID-19 疫情中,临床试验临床试验是指临床试验的临床试验.乳制品公司ibacillus.微生物组是一个微生物组.益生菌益生菌益生菌预防预防预防

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