肠道微生物群与高温和高湿度环境中的食欲抑制有关
Yalan Wu1, Xiangrong Feng1, Mengjun Li1
1Research Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangzhou, China.
EBioMedicine
|December 16, 2023
概括
高温和高湿度环境会改变肠道微生物群,导致小鼠的食欲抑制. 肠道细菌的这些变化会影响食物摄入量和体重,为代谢障碍提供了洞察力.
科学领域:
- 微生物学 微生物学
- 代谢过程中的代谢.
- 环境健康 环境健康
背景情况:
- 调节食欲对于代谢健康至关重要.
- 肠道微生物的组成影响食欲和能量平衡.
- 众所周知,高温和高湿度 (HTH) 的环境会改变肠道微生物群,但它们对食欲的直接影响尚不清楚.
研究的目的:
- 在HTH条件下调查肠道微生物群和食欲调节之间的关系.
- 阐明HTH环境对食物摄入,体重和食欲相关激素的影响.
主要方法:
- 利用人工气候盒在小鼠模型中模拟HTH环境.
- 采用便细菌移植 (FMT) 来评估肠道微生物群的因果作用.
- 应用孟德尔随机化 (MR) 分析来证实因果关系.
主要成果:
- 暴露于HTH的小鼠显示食物摄入量和体重减少,肠道微生物群发生显著改变.
- 暴露于HTH的小鼠的FMT复制了这些对食物摄入量,体重和肠道细菌的影响.
- 与食欲相关的荷尔蒙 (格雷林,GLP-1,胰岛素) 减少,而YY水平波动.
结论:
- 肠道微生物群与HTH环境中的食欲抑制密切相关.
- 肠道微生物群的HTH诱导的变化有助于改变食欲和代谢特征.
- 这些发现为环境条件对肠-大脑轴信号传递和食欲控制的影响提供了新的见解.
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