在重症患者中,给予自由氨基酸与完整蛋白质相比,改善了外源氨基酸的可用性:一项随机对照研究
Rob Jj van Gassel1, Michelle Eg Weijzen2, Imre Wk Kouw2
1Department of Surgery, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre +, Maastricht, The Netherlands; Department of Intensive Care Medicine, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre +, Maastricht, The Netherlands.
The Journal of nutrition
|December 16, 2023
概括
危急病患者与完整的蛋白质相比,自由氨基酸的氨基酸吸收得到了改善. 这增强了氨对组织的可用性,有助于恢复.
科学领域:
- 营养科学 营养科学
- 关键护理医学 关键护理医学
- 生物化学 生物化学
背景情况:
- 在重症患者中,蛋白质消化和氨基酸吸收通常会受到损害.
- 与完整的蛋白质相比,使用自由氨基酸的肠道营养可能会增加氨基酸的可用性.
研究的目的:
- 为了比较饮食衍生型氨酸的摄入量,在完整的蛋白质被肠道输入后,与危急病患者的自由氨基酸相比.
- 量化氨基酸吸收和全身蛋白质净平衡.
主要方法:
- 研究了16名机械通风重症监护室 (ICU) 患有吸收不良风险的患者.
- 患者接受了L-[环-2H5]-氨酸和L-[环-3,5-2H2]-氨酸输液.
- 他们随机通过鼻胃管在2小时内给予20克标记的完整牛奶蛋白或相当数量的标记的自由氨基酸.
主要成果:
- 随着自由氨基酸的使用,氨酸和白氨酸的度在血中增加得更快,并且在更大程度上增加.
- 与完整的蛋白质 (43.8%) 相比,与自由氨基酸 (68.7%) 相比,循环中的饮食衍生型氨基是25%以上的.
- 全身蛋白质净平衡是正的,并且倾向于对自由氨基酸更有利.
结论:
- 免费氨基酸的使用可以提高重症患者的食后血氨基酸的可用性.
- 这导致了饮食衍生的氨酸对外围组织的更大可用性.
- 这项研究已在clinicaltrials.gov注册为NCT04791774.
相关概念视频
Overview of Protein Metabolism
1.2K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
1.2K
Drug Distribution: Plasma Protein Binding
5.6K
Drugs predominantly attach to plasma proteins, with only a small percentage remaining unbound. The unbound portion can be calculated as one minus the bound fraction. Acidic drugs form large, inactive complexes by reversibly binding to plasma albumin, which prevents them from diffusing across biological barriers. These drug-protein complexes act as reservoirs for the drugs. As the concentration of unbound drugs decreases, these complexes quickly dissociate to release the free drug, maintaining...
5.6K
Proteins: Dietary Sources and Requirements
448
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
448
Acute Respiratory Failure-V
142
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
142
Factors Affecting Protein-Drug Binding: Patient-Related Factors
61
Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
61
Parentral Nutrition: Centeral and Peripheral Parental Nutrition
168
Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
168


