具有亚模拟结构的离子液体配方的设计,用于增强药物皮肤透
Takeshi Oshizaka1, Aki Yamamoto1, Hikaru Tanaka1
1Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo, Togane, Chiba 283-8555, Japan.
Journal of pharmaceutical sciences
|December 16, 2023
概括
一种新型的离子液体,IL-Azone,增强药物皮肤透效果比Azone更有效,当配制与白色石油时. 这种配方最大限度地降低了IL-Azone降解,从而导致快速和明显的药物输送.
科学领域:
- 制药科学 制药科学
- 皮肤药物输送 皮肤药物输送
- 材料科学 材料科学 材料科学
背景情况:
- 劳洛卡普拉姆 (Azone) 是一种强大的皮肤透增强剂,但会引起严重的皮肤刺激.
- 离子液体 (IL) 作为药物输送的不那么刺激的替代品具有潜力.
- 一种模仿阿的离子液体 (IL-Azone) 被开发出来,使用了不那么刺激的成分:阴离子 ε-caprolactam 和 anionic myristic acid.
研究的目的:
- 为开发的IL-Azone确定一个合适的配方.
- 为了评估IL-Azone与Azone相比,IL-Azone的皮肤透度的提高.
- 为了研究配方水含量对IL-Azone稳定性和有效性的影响.
主要方法:
- 制备了含有5%的阿或IL-阿和模型药物抗皮林的配方.
- 使用各种配方进行了皮肤透实验.
- 评估了白色石中低含水量对IL-Azone稳定性和透增强的影响.
主要成果:
- 在大多数测试的配方中,IL-Azone证明了最小的皮肤透增强.
- 当IL-Azone与白色石油相结合时,观察到皮肤透的显著和快速增强.
- 白色石油中的IL-Azone显示出比Azone更明显和更快的透增强,这归因于它在层状角膜-表皮界面的降解.
结论:
- 白色石油是IL-Azone的合适载体,由于含水量最小,可以防止其过早降解.
- 与阿相比,白色石油中的IL-Azone提供了优越和更快的药物皮肤透.
- 这种优化的配方对增强皮肤药物递送应用具有前景.
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