相关实验视频

Updated: Jul 8, 2025

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula

Published on: January 26, 2024

天然生物活性化合物和STAT3对抗肝细胞癌:最新情况

Suryaa Manoharan¹, Shreejit Saha¹, Krishnasanthiya Murugesan¹

¹Molecular Toxicology Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore 641 046, India.

|December 16, 2023

概括

天然生物活性化合物 (NBC) 在抑制信号传感器和转录3 (STAT3) 途径的激活器方面表现有前途,为治疗肝细胞癌 (HCC) 提供了一条新的途径. 这些化合物,特别是烯,显示出防止瘤发育和转移的潜力.

科学领域:

在瘤学瘤学.
自然产品化学自然产品化学
分子生物学分子生物学

背景情况:

肝细胞癌 (HCC) 是一种高度致命的肝癌.
转录3 (STAT3) 途径的信号传感器和激活器是HCC发展的关键调节器,并且在这些瘤中经常活跃.
针对STAT3途径是预防和治疗HCC的一个有希望的策略.

研究的目的:

审查天然生物活性化合物 (NBC) 在肝细胞癌中作为STAT3抑制剂的作用.
探索NBCs在预防和治疗HCC方面的潜力,特别是考虑到传统药物的副作用.
在HCC中提供NBC对STAT3废除的全面证据.

主要方法:

对调查针对HCC中STAT3途径的NBC研究的文献综述.
在体外和体内证据分析NBCs的疗效.
对NBC的分类,重点是烯,类,胡卜素和类.

主要成果:

各种NBC,特别是烯,有效地抑制STAT3核转位.
烯通过STAT3抑制降低与转移相关的关键因素,包括矩阵金属蛋白酶2 (MMP2),矩阵金属蛋白酶9 (MMP9) 和血管内皮生长因子 (VEGF).
此外,NBC还抑制抗亡蛋白和细胞周期标记物,有助于抗瘤效应.

结论:

由于它们对STAT3通路的向作用和有利的副作用概况,NBCs代表了对HCC常规疗法的可行替代方案.
烯是一种重要的NBC类,通过调节STAT3信号,在HCC中表现出广泛的抗癌作用.
对NBC的进一步研究为开发针对肝细胞癌的新型治疗策略提供了巨大的潜力.

关键词:

肝细胞癌是肝细胞癌.天然生物活性化合物天然生物活性化合物这是一种STAT3抑制剂.在STAT3信号传输中.烯是一种烯.

更多相关视频

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

Published on: August 7, 2020

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

相关概念视频

Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Drugs that Stabilize Microtubules

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...