老年人肥胖悖论 - 延迟衰老:系统性审查和元分析
Szimonetta Eitmann1, Peter Matrai1, Peter Hegyi2
1Institute for Translational Medicine, Medical School, University of Pecs, 12 Szigeti street, H-7624 Pecs, Hungary.
Ageing research reviews
|December 16, 2023
概括
在老年人中,sarcopenic肥胖 (SO) 可能会降低与sarcopenic非肥胖 (SNO) 个体相比的死亡风险. 然而,SO与较差的身体功能和较高的代谢综合征风险有关.
科学领域:
- 老年学是一门学科.
- 代谢健康 代谢健康
- 营养科学 营养科学
背景情况:
- 肥胖的预后意义在 sarcopenic 成年人仍然有争议.
- 对于老龄化的人群来说,了解sarcopenic obesity (SO) 对健康结果的影响至关重要.
研究的目的:
- 系统地审查和元分析肥胖对成年人肥胖症健康结果的影响.
- 为了比较sarcopenic肥胖 (SO) 和sarcopenic非肥胖 (SNO) 个体之间的健康结果.
主要方法:
- 在 MEDLINE,EMBASE,Scopus 和 CENTRAL 的系统文献搜索.
- 来自65项研究的数据的元分析和元回归,包括100,612名参与者.
- 考虑各种肥胖评估方法,包括身体成分测量.
主要成果:
- 在社区生活的老年SO成年人比SNO成年人死亡风险低15% (HR:0.85).
- 与SNO相比,SO患者的体力表现较低,代谢综合征风险更高.
- 在SO和SNO社区成年人中,死亡风险和HR之间观察到与年龄相关的负相关性.
结论:
- 在65岁以上,sarcopenic肥胖症可能代表生物学上较早的衰老阶段,与sarcopenic非肥胖症相比,预期寿命增加.
- 虽然额外的肥胖可能会使肉症恶化,但其预后作用因年龄和健康状况而异.
- SO与不同的健康状况有关,包括较差的身体功能和代谢健康,但与SNO相比,落和心血管疾病的风险类似.
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