肺部Mycobacterium abscessus感染在与吸入型tigecycline联合治疗时进行治疗
Andreas Arnholdt Pedersen1,2,3, Andreas Fløe4, Anders Løkke5,2
1Department of Pulmonary Research, Lillebaelt Hospital, Vejle, Denmark Andreas.Arnholdt.Pedersen@rsyd.dk.
BMJ case reports
|December 16, 2023
概括
这项案例研究表明,吸入的tigecycline有效地治疗了一个患有难以治疗的肺部Mycobacterium疹感染的患者. 治疗持续了15个月,在2年的随访期间,副作用最小,没有阳性培养.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 由Mycobacterium abscessus引起的肺部疾病带来了重大的治疗挑战.
- 目前的治疗方案是漫长的,复杂的,并与许多不良影响相关.
- 对耐火病例缺乏可靠的基于证据的治疗选择.
研究的目的:
- 评估吸入型tigecycline在患有治疗不耐药的肺 Mycobacterium abscessus 的患者中的疗效和安全性.
- 为难以治疗的M.瘤感染提出潜在的替代治疗策略.
主要方法:
- 一个单一患者的病例报告,患有耐火性肺部M. abscessus.
- 治疗通过吸入的tigecycline进行了15个月.
- 在两年内进行临床和微生物学随访.
主要成果:
- 在2年的随访期间,持续的微生物清除没有积极的真菌菌培养.
- 吸入式tigecycline治疗与相对有限的副作用有关.
- 成功管理治疗不耐用的肺部M...
结论:
- 当标准疗法失败时,吸入的tigecycline可能是肺部Mycobacterium的可行的治疗选择.
- 需要进一步的研究,以在更广泛的患者群体中探索这种治疗方法.
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