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COVID-19对癌症患者的影响

Demi Wekking¹, Thilini H Senevirathne², Josie L Pearce³

¹Amsterdam UMC, Location Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.

Cytokine & growth factor reviews

|December 16, 2023

概括

癌症患者对COVID-19疫苗的免疫反应较弱,特别是对新变种的免疫反应. 对这个脆弱群体来说,增强剂注射至关重要,以提高对严重的SARS-CoV-2感染的保护.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
传染性疾病传染性疾病

背景情况:

癌症患者对严重的COVID-19非常敏感,增加了发病和死亡风险.
晚年,吸烟,晚期疾病,化疗和ECOG评分≥2是关键的死亡风险因素.
在癌症患者中,COVID-19疫苗显示免疫反应效率降低,特别是那些患有血液性恶性瘤的人.

研究的目的:

审查COVID-19疫苗在癌症患者的有效性,包括那些接受HCT或CAR T细胞治疗的人.
在这个人群中探索对SARS-CoV-2疫苗接种的幽默和细胞免疫反应.
为了确定严重感染和低于最佳的疫苗反应的风险因素和生物标志物.

主要方法:

对癌症患者COVID-19疫苗接种研究的文献综述.
对幽默性 (抗体) 和细胞 (T细胞) 免疫反应的分析.
检查与感染严重程度和疫苗反应相关的风险因素和生物标志物.

主要成果:

在癌症患者中,疫苗诱导的免疫反应往往降低,与较低的中和抗体水平对关心的变体.
免疫力随着时间的推移而减弱,因此需要进行补充疫苗接种以获得持续的保护.
引起关注的病毒变体 (VOCs) 由于疫苗有效性降低,存在持续的挑战.

结论:

了解癌症患者对COVID-19疫苗的免疫反应对于公共卫生战略至关重要.
推给这个脆弱人群进行补充疫苗接种,以加强保护.
需要进一步研究生物标志物和改进疫苗接种策略,以优化癌症患者的SARS-CoV-2保护.

关键词:

关于COVID-19疫苗的使用情况癌症患者癌症患者免疫反应的免疫反应.这就是SARS-CoV-2病毒.

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