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Updated: Jul 8, 2025

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells
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在Komagataella phaffii中作为外来遗传物质存储库的超数合成染色体

Dariusz Abramczyk1, Maria Del Carmen Sanchez Olmos2, Adan Andres Ramirez Rojas2

  • 1School of Chemistry, University of Edinburgh, Edinburgh, UK. dabramcz@ed.ac.uk.

Microbial cell factories
|December 16, 2023
PubMed
概括

研究人员在Komagataella phaffii (Pichia pastoris) 酵母中设计了一种稳定的人工"纳米"染色体,以实现高效的生物制造. 这项技术可以通过促进多个基因的整合而产生复杂的人类蛋白质,如补充因子H,而不会导致基因组不稳定.

关键词:
人工染色体的人工染色体生物制造 生物制造补充因子 H 的补充因子 H.DNA组装组件的组装代谢工程是代谢工程.这就是Pichia pastoris.治疗性蛋白质是一种治疗性蛋白质.酵母酵母是一种酵母.

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