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Hae Chan Park¹, Hyojin Kim², Ji-Yeong Kim¹

¹Department of Otorhinolaryngology-Head & Neck Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

|December 16, 2023

概括

高PSMD1表达与口腔状细胞癌 (OPSCC) 的较差结果有关. 这一发现表明PSMD1是一种负面的预后因素,也是OPSCC患者精准医学的潜在治疗目标.

科学领域:

在瘤学瘤学.
分子病理学分子病理学

背景情况:

对头癌的化疗结果,包括口腔支状细胞癌 (OPSCC),已经有了有限的改善.
确定预后因素和治疗目标对于推进OPSCC的精准医学至关重要.
蛋白质酶子单元α型1 (PSMD1) 已成为各种癌症的潜在预后标志物.

研究的目的:

调查PSMD1表达在口腔状细胞癌 (OPSCC) 患者的预后意义.
评估PSMD1作为预测OPSCC疾病特异性存活率 (DSS) 的潜在生物标志物.

主要方法:

免疫组织化学用于评估64个OPSCC组织样本中的PSMD1表达.
组织微阵列 (TMAs) 分析了PSMD1和p16的表达,并计算了H分数.
用包括卡普兰-梅尔和考克斯回归模型在内的统计方法分析了临床病理学数据和生存结果.

主要成果:

在OPSCC患者中,高PSMD1表达 (核中的H分数≥90) 与较差的疾病特异性存活率 (DSS) 相关 (P=.006).
低PSMD1表达在早期瘤 (P=.005) 和HPV阳性病例 (P=.016) 中更为频繁.
多变量分析确定了PSMD1表达,病态T分期和样本年龄作为DSS的显著预测因素.

结论:

PSMD1 作为口腔膜状细胞癌的负预后因素.
PSMD1表达是预测OPSCC患者生存的潜在生物标志物.
在OPSCC中,PSMD1代表了未来精准医学策略和药物重新定位研究的潜在治疗目标.

关键词:

在HPV中,HPV是HPV.头癌是头部和部的癌症.免疫组织化学免疫组织化学口腔喉癌是一种癌症.蛋白质酶体抑制剂蛋白质酶体抑制剂有针对性的治疗.

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