在一位老年西班牙裔患者身上出现了一种意想不到的上非霍奇金淋巴瘤
Dalianie Nieves1, Elias Sobrino1, William Caceres-Perkins1
1Hematology-Oncology and Pathology Departments, VA Caribbean Healthcare System, San Juan, Puerto Rico.
Puerto Rico health sciences journal
|December 17, 2023
概括
外节NK/T细胞淋巴瘤 (ENKTL) 是一种罕见的癌症. 一位患有ENKTL的老年患者,最初被误诊,通过Gemcitabine-Oxaliplatin和放射治疗实现了完全的反应.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 鼻类型的外节NK/T细胞淋巴瘤 (ENKTL) 是一种罕见的非霍奇金淋巴瘤,特别是在西方国家.
- ENKTL是一种具有不良预后和不清楚最佳治疗策略的侵袭性恶性瘤.
- 目前的治疗方法,如Peg-Asparaginase (SMILE),通常用于年轻患者.
研究的目的:
- 报告老年患者最初被误诊的ENKTL病例.
- 描述修改后的治疗方法及其对老年人的有效性.
- 强调在异常呈现时考虑罕见诊断的重要性.
主要方法:
- 一个案例研究,一个85岁的男性出现了暗示半面的症状.
- 诊断成像 (CT扫描) 显示了大鼻腔病变.
- 活检证实了异端NK/T细胞淋巴瘤 (ENKTL).
- 根据患者的年龄和表现状况,调整治疗为结合放射治疗的吉姆西塔-奥沙利普拉丁 (Gemox) 化疗.
主要成果:
- 患者的最初症状被错误地归因于半面,导致Onabotulinum毒素A治疗.
- 脑电图扫描和随后的活检证实了上鼻腔的ENKTL.
- 经过修改的Gemox化疗和放射治疗方案导致了完全的反应.
- 持续负的爱斯坦·巴尔DNA标位表明了治疗的有效性.
结论:
- ENKTL可能异常呈现,并被误诊,特别是在老年患者中.
- 在老年ENKTL患者中,修改后的治疗方案 (Gemox化疗和放射治疗) 可能是有效的.
- 根据患者特定因素量身定制治疗对于管理罕见和侵袭性淋巴瘤至关重要.
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