在心血管疾病中,一些内脏感官系统的炎症和自主功能障碍
R M Lataro1, F Brognara2, R Iturriaga3
1Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
炎症会影响内脏 afferent神经,影响心血管和呼吸控制. 这篇综述详细介绍了炎症调解剂如何破坏巴罗反射和使神经末端敏感,从而促进心血管疾病的进展.
科学领域:
- 神经科学是一个神经科学.
- 心血管生理学心血管生理学
- 免疫学 免疫学 免疫学
背景情况:
- 体 afferent 敏感化和高性是心血管和呼吸系统疾病的关键.
- 炎症在调节内脏 afferent 敏感性和强度方面发挥着至关重要的作用.
研究的目的:
- 审查有关炎症如何调节内脏 afferent 敏感性的证据.
- 探索炎症媒介对心血管和呼吸系统控制的影响.
主要方法:
- 关于炎症,内脏腺体和心血管/呼吸系统的研究的文献综述.
- 分析特定炎症媒介 (例如,氧化,细胞因子) 和受体 (例如,TLR-4) 的作用.
主要成果:
- 像氧化和细胞因子这样的炎症调解剂可以抑制巴罗受体附属体,从而损害心血管疾病中的巴罗反射.
- 支持炎症的细胞因子存在于关键的神经结构 (结节腺,动脉体) 中,可以使 afferent 终端敏感.
- 动脉体可能充当系统性炎症分子的传感器,参与抗炎反射.
结论:
- 炎症显著影响内脏 afferent 信号,有助于心血管疾病的病理生理学.
- 需要进一步的研究,以阐明炎症调解剂在心血管疾病中影响内脏 afferent 信号的确切机制.
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