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黑人吸烟和多发性硬化症风险:一个嵌套的病例控制研究

Vinicius A Schoeps¹, Marianna Cortese², Kassandra L Munger²

¹Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Multiple sclerosis and related disorders

|December 17, 2023

概括

吸烟似乎不会增加黑人患多发性硬化症 (MS) 的风险. 这一发现表明,吸烟与多发性硬化症之间的联系可能因种族和民族不同而有所不同.

科学领域:

神经学神经学
流行病学流行病学
环境健康环境健康

背景情况:

吸烟是多发性硬化症 (MS) 的已知危险因素.
吸烟对不同种族和族群的MS风险的影响仍然不清楚.

研究的目的:

根据种族/种族,调查吸烟是否会影响多发性硬化症的风险.

主要方法:

进行了一项嵌套病例控制研究,使用来自美国军事人员的血清样本.
测量了患有多发性硬化症的黑人和白人个体的血清丁氨酸水平 (烟草烟雾暴露的标志物).
对照组根据年龄,性别,种族/民族,样本采集日期和军事部门进行了匹配.

主要成果:

吸烟与黑人患MS的风险增加无关 (RR:1.08).
白人吸烟与MS风险之间的关联在统计学上并不显著 (RR:1.85),但点估计与之前的研究一致.
结果在各种分析中保持一致,包括不同的吸烟状态定义和采样时间.

结论:

吸烟与多发性硬化症风险之间的关联可能因种族/种族而异.
吸烟没有被发现与黑人群体的MS风险有关,与主要白人群体的发现形成鲜明对比.

关键词:

科提宁是一种可氨酸.流行病学流行病学多发性硬化症是多发性硬化症.吸烟吸烟吸烟吸烟

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