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发现谷氨基环酶抑制剂的潜在支架:虚拟选,合成和评估

Qingqing Zhou1, Jiaxin Cai2, Feixia Qin2

  • 1School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen 518055, China.

Bioorganic & medicinal chemistry
|December 17, 2023
PubMed
概括

针对谷氨基环酶 (QC) 的新型化学支架在阿尔茨海默病 (AD) 治疗方面表现有前途. 虚拟查发现了新的QC抑制剂,为早期的AD提供了潜在的新治疗剂.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.评价 评价 评价谷氨基胺基环酸酶是什么?抑制剂是一种抑制剂.脚手架是一个脚手架.综合合成 综合合成虚拟选是一个虚拟的选.

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Enzyme Inhibition01:30

Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.