来自Stemona sessilifolia的特征性化物具有肺部保护作用
Wanru Jiang1, Bo Liu1, Gang Chen1
1School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, People's Republicof China.
Bioorganic chemistry
|December 17, 2023
概括
树根 (Stemona sessilifolia) 产生的25种类化合物具有肺部保护作用. 结核胺D通过减少氧化应激,显著地有望通过减少氧化应激来保护免受气诱导的肺损伤.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
背景情况:
- 传统上,Stemona sessilifolia的根被用于药用目的.
- 肺部损伤仍然是一个重大的健康问题,需要发现新的治疗药物.
- 茎类是一种具有多种生物活性的化合物.
研究的目的:
- 从Stemona sessilifolia根中分离和表征Stemona类化合物.
- 评估这些孤立的类化合物对化学诱导的肺损伤的肺保护作用.
- 识别关键化合物并阐明它们的作用机制,以实现潜在的治疗应用.
主要方法:
- 使用NMR光谱学和高分辨率质谱学分离和结构阐明25种Stemona化物.
- 通过超高性能液态染色学-四极飞行时间/质谱法 (UPLC-QTOF/MS) 识别化物和碎片化模式.
- 使用暴露于NNK和纳米二氧化 (nm SiO2) 的MLE-12细胞进行肺保护作用的体外评估.
- 在C57BL/6小鼠的肺损伤的体内评估由nmSiO2诱导,重点关注化合物10 (Tuberostemonine D).
主要成果:
- 他们分离了25种Stemona类化合物,包括4种新化合物和1种新天然产品.
- 一些类化合物表现出对NNK诱导的细胞损伤的保护作用,而另一些则改善了nm SiO2诱导的肺上皮细胞损伤.
- 化合物10 (Tuberostemonine D) 显著保护小鼠免受nm SiO2诱导的肺损伤,减少活性氧物种 (ROS) 和恢复SOD和MDA水平.
- 化合物10的保护机制可能涉及Nrf2激活.
结论:
- 石 (Stemona sessilifolia) 是富含生物活性类的丰富来源,具有显著的肺部保护潜力.
- 结核胺D被确定为负责肺部保护作用的关键成分,特别是在防治气引起的损伤方面.
- 对结核胺D及其Nrf2介导途径的进一步研究可能会导致肺部疾病的新型治疗策略.
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