血清克洛托与慢性病全因死亡率之间的关联:来自前性队列研究的证据
Shisheng Han1, Xiaolu Zhang1, Xiaojun Wang2
1Department of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
American journal of nephrology
|December 17, 2023
概括
高血清Klotho水平与慢性病 (CKD) 患者全因死亡率降低有关. 这种保护作用在克洛托度低于760 pg/mL时最为明显.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 生物标志物 生物标志物
- 流行病学 流行病学
背景情况:
- 慢性病 (CKD) 是一个与死亡率增加相关的全球健康问题.
- 克洛托是一种蛋白质激素,在调节矿物质和酸盐代谢方面发挥作用,在CKD中可能具有保护作用.
研究的目的:
- 调查循环可溶克洛托度与患有CKD的个体全因死亡率之间的关联.
- 探索血清克洛托度与该人群死亡风险之间的潜在非线性关系.
主要方法:
- 这是一项前性队列研究,利用了2007-2016年国家健康和营养检查调查 (NHANES) 中2456名CKD参与者的数据.
- 复杂的抽样加权多变量Cox比例危险模型和受限制的立方线分析被用于评估血清Klotho和全因死亡率之间的关联.
主要成果:
- 在平均82个月的随访期间,死亡人数为550人.
- 经过对共变量进行调整 (HR=0.96) 后,在血清Klotho每100ppg/ml增加时,观察到全因死亡风险降低了4%.
- 发现了一种显著的"L"形关联,转折点为760 pg/mL. 在这个水平以下,增加Klotho显著降低死亡风险 (HR=0.86每100 pg/mL).
结论:
- 血清Klotho水平表现出一种独特的"L"形关联,与患有CKD的个体的全因死亡率.
- 较低的克洛托度 (<760 pg/mL) 与增加的死亡风险有显著联系.
- 需要进一步的研究来验证这些发现,并探索治疗影响.
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