亚洲人群中初级视角闭眼和初级视角开眼的患病率:一个元分析和多个元回归分析
Jaekyoung Lee1, Ji Sun Park1,2, Yoon Jeong1
1Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
Korean journal of ophthalmology : KJO
|December 17, 2023
概括
在亚洲,初级闭角眼 (PACG) 与初级开角眼 (POAG) 的患病率比为2.204. 较高的POAG患病率显著预测了较高的PACG与POAG比率,这表明眼病流行病学的关键因素.
科学领域:
- 眼科医生 眼科 眼科
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 玻璃眼是不可逆转失明的主要原因,呈现出不同的亚型,在全球范围内患病率不同.
- 主要视角闭眼 (PACG) 和 主要视角开眼 (POAG) 是最常见的形式,其流行病学具有显著的区域差异.
- 了解PACG和POAG在不同人群中的相对流行率,特别是在亚洲,对于有针对性的公共卫生干预和资源分配至关重要.
研究的目的:
- 为了确定PACG与POAG在亚洲人口中的综合流行率.
- 为了确定影响不同研究中流行率异质性的因素.
主要方法:
- 对亚洲人口研究的PubMed,Embase和Cochrane数据库进行系统的文献搜索.
- 使用随机效应模型对20项研究 (52,522人) 的元分析.
- 进行元回归分析,以探索异质性的来源.
主要成果:
- 汇总的PACG与POAG流行率为2.204 (95% CI: 1.6173.004),表明PACG的流行率更高.
- 观察到显著的异质性 (p < 0.001).
- POAG流行是异质性最强的预测因素 (模型重要性:0.954),其次是大陆和出版年份.
结论:
- 在亚洲人群中,估计的PACG与POAG流行率是2.204.
- POAG的患病率是影响PACG与POAG患病率的最关键因素.
- 预计每增加1%的POAG患病率,PACG与POAG的比率将增加0.471,这突显了这些青光眼亚型之间的动态关系.
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