在患有甲状腺功能障碍的患者中,肺部和全身血动力学.
Roman Brenner1, Tilman Drescher2, Rebecca Locher3
1Department of Cardiology.
The American journal of medicine
|December 17, 2023
概括
肺高血压影响了大约三分之一的甲状腺功能障碍患者. 心脏输出量增加和左心室填充压力,而不是肺血管疾病,推动了这种联系.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 肺部病理学 肺部病理学
背景情况:
- 甲状腺功能障碍与肺高血压有关,但患病率和机制尚不清楚.
- 格雷夫斯病是甲状腺功能障碍的常见原因之一.
- 肺高血压需要在甲状腺功能高的患者进行进一步的研究.
研究的目的:
- 为了确定严重甲状腺功能障碍症中肺高血压的患病率.
- 研究甲状腺功能障碍症中肺高血压的潜在血液动力学机制.
主要方法:
- 对99名甲状腺功能过高患者进行的前性单中心研究.
- 在基线和随访时检查肺血液动力学的心声学.
- 在一小部分患者中进行右心脏导管.
主要成果:
- 31%的患者在基线时患有肺高血压.
- 血性肺动脉压力升高与左心室填充压力 (E/e) 相对应.
- 治疗后心脏输出量和心室尺寸下降;肺血管阻力保持不变.
结论:
- 肺高血压在大约三分之一的甲状腺功能过高患者中很普遍.
- 增加心脏输出和左心室填充压力是关键机制.
- 没有显著的肺血管疾病被确定为原因.
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