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SOX11+ 大B细胞新生体:循环蛋白D1阴性黑状/多形地幔细胞淋巴瘤或大B细胞淋巴瘤?

Shaoying Li¹, Guilin Tang¹, Preetesh Jain²

¹Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

|December 17, 2023

概括

具有SOX11阳性的大型B细胞瘤经常被错误诊断. 这项研究表明,SOX11是循环素D1阴性布拉斯/形地幔细胞淋巴瘤 (MCL) 的特定标志物,与DLBCL或HGBL区分开来.

科学领域:

血液病理学血液病理学
在瘤学瘤学.
分子诊断学分子诊断学

背景情况:

大型或状B细胞瘤中SOX11表达具有诊断挑战,通常导致差异性诊断,包括地幔细胞淋巴瘤 (MCL),扩散大B细胞淋巴瘤 (DLBCL) 和高等级B细胞淋巴瘤 (HGBL).
区分这些实体对于准确的患者管理和治疗至关重要.

研究的目的:

为了研究SOX11表达在大型或状B细胞瘤中的诊断效用.
为了确定SOX11阳性瘤是否可以可靠地被归类为循环素D1阴性布拉斯/多形MCL.

主要方法:

对13种SOX11阳性大/状B细胞瘤队列的分析.
在CCND1和CCND2重排列中进行光现场杂交 (FISH).
基因表达概况 (GEP) 和主要成分分析 (PCA).
在85个DLBCL和24个HGBL病例中进行了SOX11表达调查.

主要成果:

在所有情况下,FISH分析对CCND1重新排列是负的;在12.5%的受试病例中观察到CCND2重新排列,在25%的受试病例中观察到额外复制.
GEP和PCA表明,SOX11阳性队列的基因表达特征类似于环素D1阳性MCL,并与MCL病例重叠,但不是DLBCL.
在调查的病例中,SOX11表达显示出100%的特异性和MCL诊断的积极预测值.

结论:

对SOX11阳性的大型或状B细胞瘤应归类为循环素D1阴性状/形MCL,而不是DLBCL或HGBL.
SOX11是MCL的高度特异性标记物,包括循环素D1阴性变体.
建议对布拉斯型/大B细胞新生体进行常规SOX11测试,以确定潜在的cyclin D1阴性布拉斯型/pleomorphic MCL病例.

关键词:

CCND1 一个人的生活 CCND2 在线阅读环林D1阴性地幔细胞淋巴瘤.在SOX11中,SOX11是什么?布拉斯托型高度B细胞淋巴瘤布拉斯托伊德/形形态的扩散大的B细胞淋巴瘤.

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