超声波激活探头用于疾病成像和治疗的体内生殖器
Xing Liu1, Jimei Wang2, Ying Wu2
1Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Advanced drug delivery reviews
|December 17, 2023
概括
声动疗法 (SDT) 使用超声波激活声敏化剂,产生反应性氧物种 (ROS) 以向瘤细胞死亡. 本综述涵盖了用于通过SDT改进成像和更深层次的瘤治疗的声敏化剂的开发.
科学领域:
- 生物医学工程 生物医学工程
- 在瘤学瘤学.
- 材料科学 材料科学 材料科学
背景情况:
- 声动力疗法 (SDT) 利用超声波 (US) 激活声敏化剂,产生针对癌细胞死亡的活性氧物种 (ROS).
- 美国的深层组织透使SDT能够治疗体内更深处的瘤,对周围健康组织的影响最小.
- 声敏剂对于SDT的有效性至关重要,推动了对具有增强治疗性能的新材料的研究.
研究的目的:
- 审查超声波启发的超声波敏化器在成像和治疗应用中的进展.
- 评估各种无机,有机和混合声敏剂的结构和性能.
- 讨论以图像为导向的SDT策略,并确定该领域的关键挑战和潜在解决方案.
主要方法:
- 对声敏化器开发的文献综述.
- 对无机,有机和混合型声敏剂类型的评估.
- 分析图像引导的声动力学治疗方法.
主要成果:
- 不同的声敏剂类别的分类和性能评估.
- 图像引导SDT技术的概述. 图像引导SDT技术的概述.
- 确定当前的挑战和未来的研究方向.
结论:
- 声敏剂对于有效的SDT至关重要,目前的开发重点是无机,有机和混合材料.
- 图像引导的SDT为更深层的瘤提供了有针对性的治疗,显示出显著的临床潜力.
- 需要进一步的研究来克服现有的挑战,并优化SDT以更广泛的临床应用.
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