来自Garcinia esculenta Y. H. Li Y. H. Li 的细胞毒性脱和桑
Feng-Zhi Shi1, Yin-Dong Fang2, Min Fan1
1College of Pharmacy, Dili University, Dali 671000, People's Republic of China.
Fitoterapia
|December 17, 2023
概括
研究人员从Garcinia esculenta中分离出六种新型化合物,包括depsidones,一个prenylated xanthone和二次性xanthones. 加尔西库伦桑 (3) 对肺癌A-549细胞显示显著的细胞毒性.
科学领域:
- 自然产品化学 自然产品化学
- 药用化学 医学化学
- 药理学是指药理学,即药理学是指药理学.
背景情况:
- 加尔西尼亚种类是生物活性二次代谢物的丰富来源.
- 众所周知,桑和司具有多种不同的药理活动.
研究的目的:
- 从Garcinia esculenta中分离和描述新的化合物.
- 评估与人类癌症细胞系对隔离化合物的细胞毒性潜力.
主要方法:
- 使用色谱技术分离化合物.
- 通过HRESIMS,1D/2D NMR和ECD计算来阐明结构.
- 对HL-60,A-549,SMMC-7721,MDA-MB-231和SW480细胞系进行细胞毒性测定.
主要成果:
- 他们发现了六种新的化合物:两个depsidones (garciculendepsidones A和B),一个prenylated xanthone (garciculenxanthone) 和三个二维的xanthones (bigarciculenxanthones A-C).
- 化合物3-5表现出细胞毒性活性.
- 加尔西库伦桑 (3) 对肺癌A-549细胞具有强烈的细胞毒性,其IC50为8.2μM.
结论:
- Garcinia esculenta是一种有价值的结构多样化和潜在的治疗性化合物的来源.
- 加尔西库伦桑 (Garciculenxanthone) (3) 显示出作为肺癌治疗开发中的化合物的前景.
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