现实世界治疗模式和高级细胞癌患者的有效性:全国性的观察性研究
Laurence Albigès1, Carine Bellera2, Sébastien Branchoux3
1Institut Gustave Roussy, Paris, France.
Clinical genitourinary cancer
|December 17, 2023
概括
现实数据显示,先进细胞癌 (aRCC) 患者接受一线和二线全身疗法治疗的生存率有限. 这凸显了需要新的治疗方法来改善aRCC的结果.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學.
- 药理学 药理学是指药理学的学科.
背景情况:
- 晚期细胞癌 (aRCC) 的治疗环境正在迅速发展.
- 有限的现实世界数据存在于当前的治疗模式和aRCC的有效性.
研究的目的:
- 描述一线和二线aRCC中全身疗法的现实世界治疗模式.
- 评估这些治疗方法在ARCC中的有效性.
主要方法:
- 从法国全国医疗保险数据库 (SNDS) 中,从2016年开始对aRCC进行一线治疗的1629名患者中确定了一个队列.
- 对患者进行了随访,直到死亡,失去随访或2019年12月31日.
- 总体存活率 (OS) 和时间到下一次治疗或死亡 (TNT-D) 估计使用卡普兰-梅尔分析.
主要成果:
- 大多数患者 (91.7%) 接受了氨酸激酶抑制剂 (TKI) 作为一线治疗,主要是sunitinib.
- 53.5%的人接受了二线治疗,其中43.7%的人使用了尼沃卢马布.
- 中位数OS为20.7个月 (一线) 和15.4个月 (二线);中位数TNT-D为9.3个月 (一线) 和6.9个月 (二线).
结论:
- 这项研究揭示了晚期细胞癌患者的有限生存结果.
- 这些发现为评估新的治疗策略提供了至关重要的基准.
- 显著需要创新的治疗方法,包括基于免疫检查点抑制剂的组合,作为一线护理标准.
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