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Updated: Jun 11, 2026

Isolation of Leukocytes from the Human Maternal-fetal Interface

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Published on: May 21, 2015

在预测早产时产生的母亲血清中介质素-1β,FoxO1和Sestrin2水平上

Asuman Akkaya Fırat¹, Aysegül Özel², Ebru Alıcı Davutoğlu²

¹Department of Medical Biochemistry, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Türkiye.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

|December 18, 2023

概括

威胁过早分娩 (TPL) 怀孕时IL-1β和FoxO1的血清水平升高,而Sesn2水平较低. 这些生物标志物可能有助于区分早产和到期分娩.

科学领域:

生殖生物学生殖生物学
生物化学生物化学
免疫学免疫学免疫学

背景情况:

受到威胁的早产 (TPL) 是怀孕中的一个重要问题,需要准确的诊断标记.
介质素-1β (IL-1β),叉头盒蛋白O1 (FoxO1) 和细胞因子信号传递抑制剂2 (Sesn2) 都与怀孕期间的炎症和压力反应有关.

研究的目的:

调查TPL和没有并发症怀孕的妇女之间的IL-1β,FoxO1和Sesn2母体血清度的差异.
评估这些生物标志物的潜力,以区分TPL组内的早产 (PD) 和终产 (TD).

主要方法:

从54名TPL妇女和26名健康孕妇中采集了母亲血清样本.
根据分娩妊娠年龄,TPL组被分为早产 (PD) 和终产 (TD) 子组.
血清IL-1β,FoxO1和Sesn2的水平使用酶相关免疫吸收试验 (ELISA) 来量化.

主要成果:

与对照组相比,PD和TD组的血清IL-1β和FoxO1水平显著更高.
血清IL-1β和FoxO1水平在PD组明显高于TD组.
血清Sesn2水平在对照组明显高于TD组,在TD组高于PD组.
在妊娠周和血清IL-1β (r=-0.722) 和FoxO1 (r=-0.625) 之间发现了负相关性.
在妊娠周和血清Sesn2 (r=0.507) 之间观察到正相关性.

结论:

血清IL-1β和FoxO1的升高,再加上Sesn2的降低,可能作为区分早产和早产的潜在生物标志物.
这些发现突显了炎症和压力相关途径在受到威胁的早产及其结果中的作用.

关键词:

在FoxO1中,FoxO1是指FoxO1的类型.这就是Sestrin2的原因.过早分娩过早分娩是什么互乐金-1ββ的作用

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