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Updated: Jul 8, 2025

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
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阿尔法-同核素通过与BAF复合体相互作用,促进PRMT5介导的H4R3me2s基因组甲基化

Takaaki Nakamura1,2, Naoto Sugeno1, Takafumi Hasegawa1

  • 1Division of Neurology, Department of Neuroscience & Sensory Organs, Tohoku University Graduate School of Medicine, Sendai, Japan.

The FEBS journal
|December 18, 2023
PubMed
概括

核中的α-synuclein (αS) 与染色体重塑剂相互作用,通过改变基因组甲基化和降低NRCAM调节来破坏帕金森病模型中的神经元分化. 这突显了αS在神经退行过程中的核功能.

关键词:
在BAF复杂的 BAF复杂.在PRMT5中,我们使用了PRMT5.帕金森病的疾病.这是一种α-synuclein.基因组胺甲基化 基因组胺甲基化

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