甲基胺对心室再极化参数的影响,儿童注意力缺陷多动性障碍
Yaşar Tanır1, Muhammed Furkan Erbay1, Selçuk Özkan2
1Department of Child and Adolescent Psychiatry, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
长效甲基 (MPH) 可能通过影响心室再极化,增加患有ADHD的儿童心律失常的风险. 对这些患者来说,无论MPH剂量或持续时间,心脏监测至关重要.
科学领域:
- 心脏病学 心脏病学
- 儿科 儿科 儿科
- 心理药理学 心理药理学
背景情况:
- 长效甲基 (MPH) 是一种常见的治疗注意力缺陷多动症 (ADHD).
- 由于影响心室再极化,MPH可能会增加致命心律失常的风险.
- 电心电图 (ECG) 参数,如QT间隔,纠正的QT (QTc) 和T-峰到T-终点 (TpTe) 是心室再极化的主要指标.
研究的目的:
- 调查长期使用甲基胺 (MPH) 对儿童多动症患者心电图 (ECG) 参数的影响.
- 评估MPH在被诊断患有多动症的儿童中可能产生的前发律效应.
主要方法:
- 长期使用MPH的52名ADHD儿童队列与51名年龄和性别匹配的健康对照进行了比较.
- 分析了关键的心电图参数,包括QT,QTc,TpTe间隔和它们的比率.
- 记录了治疗持续时间和MPH剂量,并与心电图结果相关联.
主要成果:
- 与对照组相比,在MPH治疗中患有ADHD的儿童表现出明显延长的P波分散,TpTe间隔,TpTe分散和TpTe/QTc比率 (P < .001).
- 这些心电图变化与MPH剂量或治疗持续时间没有明显的相关性.
- 大约一半的ADHD患者的QTc值≥460毫秒,根据治疗参数没有显著差异.
结论:
- 长期使用甲基化物 (MPH) 可能与儿科ADHD患者的前节律效应有关.
- 这些效应似乎不依赖于剂量或受治疗持续时间的影响.
- 由于潜在的前节律失常风险,建议定期对接受MPH治疗的ADHD儿童进行心脏监测.
更多相关视频
13:09Using Brain Activation nir-HEG/Q-EEG and Execution Measures CPTs in a ADHD Assessment Protocol
Published on: April 1, 2018
05:48The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
Published on: June 12, 2020
相关概念视频
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers
Adrenergic Agonists: Mixed-Action Agents
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers
Verapamil, a calcium channel blocker, inhibits calcium movement across myocardial cell membranes and vascular smooth muscle. This results in the dilation of coronary and...
Drugs Affecting Neurotransmitter Release or Uptake
