在接受脏移植的接受者中,西洛利木斯与低剂量延长释放塔克罗利木斯联合使用
Zhi-Yu Zou1, Lin-Rui Dai1, Yi-Bo Hou1
1Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Organ Transplantation, Ministry of Education, and NHC Key Laboratory of Organ Transplantation, and Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China.
Frontiers in medicine
|December 18, 2023
概括
赛洛 (SRL) 加上低剂量延长释放塔克罗 (LER-TAC) 为移植接受者提供了安全有效的标准免疫抑制替代方案. 这种方案改善了移植功能和患者对药物的坚持.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫抑制是一种免疫抑制.
- 移植 移植 移植 移植
背景情况:
- 长期的合移植存仍然是一个重大的临床挑战.
- 氨酸抑制剂 (CNI) 与毒性有关,可能影响移植的存活.
- 改善药物坚持对于最佳的移植结果至关重要.
研究的目的:
- 为了比较西罗 (SRL) 与低剂量延长释放塔克罗 (LER-TAC) 相结合的疗效和安全性,与接受脏移植的接受者的标准免疫抑制.
- 评估这种转换对移植功能,排斥率和药物坚持的影响.
主要方法:
- 追溯性,观察性,单中心研究,利用倾向性得分匹配 (PSM).
- 将SRL+LER-TAC治疗的56名患者与接受基酸+标准剂量塔克罗利斯治疗的56名患者进行了比较.
- 在12个月的随访期间评估了疗效,安全性和药物坚持.
主要成果:
- 两组之间移植存活率,接受者存活率或急性排斥率没有显著差异 (p=1,000).
- 在SRL + LER-TAC组中,转换后的平均估计膜过率 (eGFR) 得到改善 (p<0.05).
- 转换后12个月,药物坚持显著改善 (p=0.002).
结论:
- 在SRL+LER-TAC方案的有效性和安全性不低于接受移植的接受者的标准免疫抑制.
- 这种替代性免疫抑制策略可能会增强移植功能.
- 转换为SRL + LER-TAC可以使移植患者更好地遵守药物治疗.
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