4D生物打印的自折叠脚手架在气管工程中增强软骨形成
bioRxiv : the preprint server for biology
|December 18, 2023
概括
这项研究介绍了用于气管组织工程的4D生物打印,自折叠的支架. 这种动态支架促进了原生细胞的软骨形成,为目前的气管修复方法提供了一个有希望的替代方案.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 再生医学是一种再生医学.
背景情况:
- 气管缺陷正在增加,特别是在儿科患者中,目前的治疗方法缺乏再生能力.
- 现有的生物移植和合成假肢无法有效地模仿自然气管结构和功能.
- 生物打印提供了一种创新的方法,用于创建气管置换的生物仿真支架.
结论:
- 4D生物打印支架有效指导eCPC分化到成熟的软骨.
- 细胞对脚手架的折叠和曲率做出反应,这对于开发工程气管软骨至关重要.
- 这种4D生物打印方法对先进的气管组织工程和再生疗法具有重大潜力.
相关概念视频
Carbon Skeletons
Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side chains...
Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.


