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Updated: Jun 27, 2026

Analysis of Dendritic Spine Morphology in Cultured CNS Neurons
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马克1调节树状脊柱形态发生和认知功能in vivo

Emily C Kelly-Castro, Rebecca Shear, Ankitha H Dindigal

    bioRxiv : the preprint server for biology
    |December 18, 2023
    PubMed
    概括

    微管类亲和调节酶1 (MARK1) 对于树突脊柱的形成和认知功能至关重要. 失去MARK1会影响小鼠的学习,记忆和类似焦虑的行为.

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    Neurogenesis and Regeneration of Nervous Tissue01:15

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    In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...