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Updated: Jun 25, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
12:22

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

Published on: April 2, 2012

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一个皮模型来研究简单疹病毒的重新激活和复发性疾病

Drake T Philip1, Nigel M Goins1, Helen M Lazear1

  • 1Department of Microbiology & Immunology, University of North Carolina at Chapel Hill.

bioRxiv : the preprint server for biology
|December 18, 2023
PubMed
概括

研究人员开发了一种新的小鼠模型来研究单纯疹病毒 (HSV) 的重新激活. 在受感染的皮肤上皮可靠地触发了复发的HSV病变,有助于研究终身感染和治疗方法.

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Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

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相关概念视频

Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...