激发性突触的天体细胞覆盖率与初级视觉皮层中突触结构和功能的测量相关
Connon I Thomas1, Melissa A Ryan1,2, Micaiah C McNabb1,3
1Electron Microscopy Core Facility, Max Planck Florida Institute for Neuroscience, 1 Max Planck Way, Jupiter, FL 33458, USA.
bioRxiv : the preprint server for biology
|December 18, 2023
概括
大脑突触的星细胞覆盖与突触结构和功能相关. 这种星细胞 - 突触相互作用影响视觉皮层的感官处理可靠性.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 突触性可塑性 突触性可塑性
背景情况:
- 哺乳动物大脑中的激发性突触通常由天体细胞接触,形成三方突触.
- 这种天体细胞 - 突触接口对谷氨酸代谢和突触动力学至关重要.
- 脑区和物种之间的星细胞覆盖率的变化及其功能影响尚未得到充分理解.
研究的目的:
- 调查突触的天体细胞覆盖和它们在体内功能性质之间的关系.
- 描述围突触星细胞过程 (PAP) 接触鱼视觉皮层中的突触.
- 检查PAP覆盖与突触强度和感官唤起的活动的关系.
主要方法:
- 在子视觉皮层中的相对光和电子显微镜.
- 对接触金字塔神经元突触的围突触星球细胞过程 (PAP) 的表征.
- 与突触大小,复杂性和 (Ca2+) 活性相关的PAP覆盖面的分析.
主要成果:
- 几乎所有激发性突触都与PAP接触,大多数接触沿着轴突-脊柱接口 (ASI).
- PAP覆盖程度与突触大小和复杂性正相关.
- PAP覆盖范围根据突触Ca2+对视觉刺激反应的选择性和唤起突触后Ca2+事件的可靠性进行缩放.
结论:
- 星细胞覆盖与视觉皮层激发性突触的结构特征密切相关.
- 星细胞覆盖有助于在个别突触的感官激活的可靠性.
- 这项研究强调了星体细胞在突触处理和感官感知中的功能作用.
相关概念视频
Neuron Structure
13.0K
Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
13.0K
Vision
53.5K
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
53.5K
Anatomy of the Eyeball
7.1K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
7.1K
Motor and Sensory Areas of the Cortex
3.9K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
3.9K
Visual System
585
Light enters the eye through the cornea, a transparent, dome-shaped surface covering the surface of the eyeball that helps to direct and focus incoming light. This light is then channeled toward the pupil, an adjustable opening whose size is controlled by the iris. The iris, a pigmented muscle, regulates the amount of light entering the eye by contracting or dilating the pupil, thereby ensuring optimal light levels for clear vision.
Once through the pupil, the light passes through the lens, a...
Once through the pupil, the light passes through the lens, a...
585
Association Areas of the Cortex
5.4K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
5.4K


