皮肤上的共体细菌会加剧炎症并延迟皮肤的愈合
Veda D Khadka1,2, Laura Markey1,2, Magalie Boucher3
1Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology; Cambridge, MA, United States.
bioRxiv : the preprint server for biology
|December 18, 2023
概括
将开始性皮肤细菌应用于受损皮肤延迟了伤口修复和增加了炎症. 这表明在开发皮肤微生物作为伤口愈合益生菌时需要谨慎.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 皮肤微生物组发挥着双重作用,提供免疫效益,同时构成感染风险.
- 像*Staphylococcus epidermidis*这样的共生细菌可以保护伤口,但它们在同时损伤皮肤时的影响尚不清楚.
- 对治疗皮肤疾病的益生菌疗法的兴趣日益增长,需要对微生物-损伤相互作用的研究.
研究的目的:
- 研究将高剂量开始性皮肤细菌应用于损伤的皮肤对屏障修复的影响.
- 了解在受损皮肤上开始性暴露后的炎症和细胞反应.
主要方法:
- 磨损的小鼠皮肤被高剂量各种开始性皮肤细菌治疗.
- 随着时间的推移,评估了皮肤屏障的修复.
- 分析了炎症,中性粒细胞透,纤维细胞活性和单细胞分化.
- 进行了转录基因分析,以了解涉及的分子途径.
主要成果:
- 皮肤微生物组的抗生素耗尽延迟了伤口的修复.
- 开始生长的动物 (*S. xylosus*, *S. epidermidis*,和其他人类开始生长的动物) 的应用也显著延迟了屏障修复.
- *S. epidermidis*暴露在4小时内引起炎症,持续4天.
- 观察到慢性伤口类炎症,中性粒细胞,纤维细胞增加,单细胞分化减少.
- 转录组学表明,上调的增殖途径抑制了修复进展.
结论:
- 在高剂量应用于损伤的皮肤的共体皮肤细菌可以阻碍屏障修复.
- 炎症反应和细胞活动的改变表明,复杂的相互作用会阻碍愈合.
- 这些发现凸显了在开发皮肤共生菌作为治疗用途益生菌时需要仔细考虑的必要性.
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