相关实验视频

Updated: Jul 8, 2025

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization

Published on: December 3, 2020

在小鼠和人类中,SIRPα控制了CD47依赖的血小板清除

Maia Shoham^1,2, Ying Ying Yiu^1,2, Paige S Hansen^1,3

¹Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.

bioRxiv : the preprint server for biology

|December 18, 2023

概括

CD47-SIRPα通路调节了血小板的清除. 阻止这种途径会影响血小板水平,而SIRPA基因表达的变化会影响血小板数量和抗CD47治疗结果.

科学领域:

免疫学免疫学免疫学
血液学血液学血液学
在瘤学瘤学.

背景情况:

癌细胞上的CD47蛋白调解免疫逃避和瘤进展.
与SIRPα结合的CD47抑制了 fagocytosis,影响了细胞清除.
CD47阻断是一种有前途的免疫瘤疗法,但可能导致血小板缺血.

研究的目的:

调查CD47-SIRPα信号在血小板恒温和清除中的作用.
了解CD47-SIRPα轴阻塞对血小板水平的影响.
为了确定影响血小板水平的遗传因素与SIRPA相关.

主要方法:

研究了CD47-SIRPα轴在血小板调节中的作用.
分析了CD47-SIRPα阻断对小鼠和人类血小板计数的影响.
检查了SIRPA位点的遗传变异及其与人类血小板水平的关联.

主要成果:

血小板的恒常清除是由CD47-SIRPα轴调节的.
治疗阻断CD47-SIRPα显著影响血小板水平.
在人类中,较高的SIRPA基因表达与较高的血小板水平相关.

结论:

CD47-SIRPα轴对血小板恒温至关重要.
了解SIRPA变异对于预测抗CD47治疗副作用很重要.
针对CD47-SIRPα通路需要仔细考虑血小板水平调节.

更多相关视频

Purification of Platelets from Mouse Blood

Purification of Platelets from Mouse Blood

Published on: May 7, 2019

Ferric Chloride-induced Murine Thrombosis Models

Ferric Chloride-induced Murine Thrombosis Models

Published on: September 5, 2016

相关概念视频

Formation of the Platelet Plug

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...