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12个月以上的康复期患者的SARS-CoV-2幽默性免疫反应揭示了严重性依赖于抗体的动态

Nadia Siles¹, Maisey Schuler¹, Cole Maguire¹

¹Department of Neurology, Dell Medical School, University of Texas at Austin, Austin, Texas.

medRxiv : the preprint server for health sciences

|December 18, 2023

概括

对COVID-19的抗体反应因疾病严重程度而异. 受体结合域 (RBD) 抗体比核体 (N) 抗体持久更长时间,提供了对重重感染的潜在保护.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
传染性疾病传染性疾病

背景情况:

了解SARS-CoV-2抗体动力学对于管理COVID-19再感染和优化疫苗至关重要.
抗体长寿为公共卫生策略和治疗干预提供了信息.

研究的目的:

评估康复个体对SARS-CoV-2核体 (N) 和受体结合域 (RBD) 的抗体反应的持续时间和水平.
根据COVID-19疾病严重程度和感染后12个月的时间比较抗体标位.

主要方法:

在98名康复参与者和17名对照者中,对抗体标位 (抗N和抗RBD) 的纵向分析.
在阳性PCR测试后的1,3,6个月和12个月进行了测试.
评估了与疾病严重程度 (无症状至严重) 和疫苗接种状态的相关性.

主要成果:

较高的初始抗N和抗RBD标位与急性COVID-19严重性增加相关.
抗N和抗RBD标位在12个月内下降,住院患者的衰退速度更快.
几乎所有参与者都保持了12个月的抗RBD标位高于控制水平,与抗N标位不同.

结论:

与COVID-19后的核体 (N) 抗体相比,受体结合域 (RBD) 抗体反应的寿命更长.
持续的抗RBD标位表明潜在的长期保护,防止严重的SARS-CoV-2再感染.
抗体动态与最初的疾病严重程度和住院状态有很大不同.

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