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肠干细胞LGR5+显示性别依赖的放射性敏感性

Ryan C Zitter, Rishi Man Chugh, Payel Bhanja

bioRxiv : the preprint server for biology

|December 18, 2023

概括

男性和女性的肠道对辐射的反应不同. 男性的肠道表现出更高的辐射敏感性和氧化应激,这一发现在各个年龄段一致,并在人类器官中得到验证.

科学领域:

在瘤学瘤学.
辐射生物学辐射生物学
胃肠病学胃肠病学

背景情况:

放射性敏感性对于辐射治疗结果至关重要.
肠道辐射毒性仍然是一个临床挑战.
放射治疗结果的性别特异性差异是建议的,但研究不足.

结论:

在肠道上皮质辐射敏感性中表现出明显的性别特异性.
确定了男性的氧化应激增加和线粒体代谢作为潜在的机制.
这些发现强调了在治疗胃肠道恶性瘤的放射治疗中考虑性别的重要性.

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