线粒体DNA拷贝数量 喘风险,严重程度和恶化变化的变化
Weiling Xu1, Yun Soo Hong2, Bo Hu3
1Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio.
medRxiv : the preprint server for health sciences
|December 18, 2023
概括
线粒体功能障碍与喘有关. 在喘患者中,较高的线粒体DNA复制数 (mtDNA-CN) 表明喘恶化较少,这表明喘严重程度的保护作用.
科学领域:
- 肺部医学 肺部医学
- 线粒体生物学 线粒体生物学
- 免疫学 免疫学 免疫学
背景情况:
- 呼吸道氧化应激和炎症是喘的关键因素.
- 线粒体功能障碍在喘风险,严重程度和恶化中的作用尚不清楚.
- 线粒体是氧化剂生成和炎症的核心.
研究的目的:
- 为了研究线粒体DNA拷贝数 (mtDNA-CN),线粒体功能的标志物,和喘之间的关联.
- 探索mtDNA-CN与喘诊断,严重程度,氧化应激和恶化的关系.
主要方法:
- 线粒体DNA复制数 (mtDNA-CN) 用来自两个队伍的血液样本进行测量:英国生物银行 (UKB) 和严重喘研究计划 (SARP).
- 在UKB中,mtDNA-CN在轻度/中度至重度喘患者和非喘患者之间进行了比较.
- 在SARP中,分析了mtDNA-CN关于喘严重程度,氧化应激生物标志物和恶化频率.
主要成果:
- 在UKB中,喘患者 (n=29,768) 的mtDNA-CN显著低于非喘患者 (n=239,158).
- 线粒体DNA拷贝数在两个队列中都没有根据喘严重程度有显著差异.
- 喘患者表现出较高的炎症标志物 (白血球,中性粒细胞,乙蛋白细胞,FENO) 和较低的超氧化物失调酶 (SOD),表明氧化应激增加.
- 在SARP中,较高的mtDNA-CN与随后一年发生三次或更多恶化的风险降低有关 (OR0.352).
结论:
- 喘与线粒体功能障碍有关.
- 升高的mtDNA-CN可能会识别出一种抗恶化喘表型.
- 线粒体功能在确定喘恶化风险方面似乎至关重要.
相关概念视频
Animal Mitochondrial Genetics
7.6K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
7.6K
Comparing Copy Number Variations and SNPs
17.7K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
17.7K
Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Asthma-III: Symptoms and Complications
2.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.5K
Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Asthma: Pathogenesis and Management
411
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
411


