相关实验视频
Updated: Jul 8, 2025

08:07
Simple Detection of Primary Cilia by Immunofluorescence
Published on: May 15, 2020
10.9K
在分化颗粒细胞神经元中,细胞内初级毛囊的永久解构
Carolyn M Ott1, Sandii Constable2, Tri M Nguyen3,4
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
bioRxiv : the preprint server for biology
|December 18, 2023
概括
大脑小粒细胞的原始细胞使用初级毛来检测声波刺的增殖. 区分神经元经历独特的纤毛脱构,在成年时变得不结合,可能会限制刺信号传递.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 发展生物学 发展生物学
背景情况:
- 小脑颗粒细胞原始体上的初级毛对于检测声波刺信号来说至关重要,这驱动了增殖.
- 在神经元分化过程中,这些初级乳毛的命运和动态在很大程度上是未知的.
- 大脑小粒细胞是大脑中最丰富的神经元类型,使其发育过程具有重要意义.
结论:
- 颗粒细胞的祖先拥有隐藏的初级毛,在分化过程中经历解构,可能是为了调节声波刺的响应能力.
- 这种纤维膜解构机制可以作为纤维膜在其他细胞类型的分化过程中去除纤维膜的模型.
- 成熟颗粒细胞中初级毛的丧失与它们在其他毛神经元中的重要作用形成鲜明对比,这表明它们具有专门的功能.
更多相关视频
相关概念视频
Microtubules in Signaling
1.7K
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
1.7K
Assembly of Complex Microtubule Structures
1.8K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
1.8K
Mechanism of Ciliary Motion
3.7K
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
3.7K

